题目：Grand Biological Universe: The geometric construction of genome space and its applications

报告人: 丘成栋 研究员（北京雁栖湖应用数学研究院）

摘要：Imitating Hilbert who proposed 23 problems in mathematics in 1900, Defense Advanced Research Projects Agency (DARPA) proposed 23 problems in pure and applied mathematics in 2008. These problems will prove to be very influential for the development of mathematics in the 21st century.

In the DARPA problems, we are asked to understand “The Geometry of Genome Space” (the number 15) and “What are the Fundamental Laws of Biology” (the number 23). Our convex hull principle for molecular biology states that the convex hull formed from Natural Vectors of one biological group does not intersect with the convex hull formed from any other biological group. This can be viewed as one of the Fundamental Laws of Biology for which DARPA has been looking for since 2008. On the basis of the convex hull principle, we can construct the geometry of the genome space. Our goal is to construct the genome spaces of seven kingdoms with Natural Metrics. These metrics are quite different in each genome space because different dark matter and dark energy may bend space-time as predicted by Einstein’s theory. As applications, we provide the first mathematical method to find undiscovered genome sequence. Our theory allows us to explore the phylogenetic relationships of biological sequences and where SARS-CoV-2 originated from. It provides a novel geometric perspective to study molecular biology. It also gives an accurate way for large-scale sequences comparison in real-time manner.

  报告时间： 2024年5月24日 15：30 -16：30

报告地点：教二楼927